Description

Keliximab CAS NO 174722-30-6 is a chimeric monoclonal antibody specifically designed to target the CD4 receptor on T-cells. This targeted mechanism of action makes it a critical research tool and a candidate for therapeutic development in immune-mediated conditions. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on immunology and autoimmune disease.

Application

• Immunological Research: A key reagent for studying T-cell function, activation pathways, and immune regulation in vitro and in vivo.
• Autoimmune Disease Investigation: Used in preclinical models to explore therapeutic potential for conditions like rheumatoid arthritis, psoriasis, and multiple sclerosis.
• Biopharmaceutical Development: Serves as a reference standard or a lead compound in the development of novel immunomodulatory biologics.
• Mechanism of Action Studies: Employed to elucidate the role of CD4+ T-cells in various disease pathologies and treatment responses.

Basic Information

Product Name	Keliximab
CAS No.	174722-30-6
Molecular Formula	Contact for details
Molecular Weight	Approx. 150 kDa (Contact for exact specification)
Synonyms	IDEC-CE9.1; Anti-CD4 Monoclonal Antibody (cM-T412); Chimeric Anti-CD4; cM-T412; IDEC CE9.1; Keliximab (USAN); Anti-Human CD4 Antibody
EINECS	Contact for details

Quality Control

Our Keliximab is produced and tested under stringent conditions to ensure high purity, biological activity, and consistency for research applications. Each batch is characterized using advanced analytical techniques, including SDS-PAGE, HPLC-SEC for purity, and functional assays to confirm CD4 binding activity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, endotoxin levels, and sterility is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. Handle as a biological material under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE / HPLC)	Corresponds to reference standard
Purity (HPLC-SEC)	≥ 95%
Protein Content (UV Absorbance)	As per COA
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Binding Assay)	Meets reference standard
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.