Description

n-Phthalyl-D-Glutamine is a high-purity, chiral glutamic acid derivative where the amino group is protected by a phthaloyl group. This compound is a critical building block in the synthesis of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected D-glutamine residue in solid-phase and solution-phase peptide synthesis, enabling the construction of specific peptide sequences.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway research, and proteomics.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, including advanced polymers and liquid crystals.
• Academic & Industrial R&D: A valuable tool for medicinal chemistry programs and the development of new synthetic methodologies.

Basic Information

Product Name	n-Phthalyl-D-Glutamine
CAS No.	174591-46-9
Molecular Formula	C₁₄H₁₄N₂O₅
Molecular Weight	290.27 g/mol
Synonyms	D-Glutamine, N-phthaloyl-; Phthaloyl-D-glutamine; (R)-2-(1,3-Dioxoisoindolin-2-yl)-5-aminopentanedioic acid; N-Phthaloyl-D-glutamic acid diamide; N-Phthalimido-D-glutamine; D-Glutamine, N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-; 174591-46-9; N-Pht-D-Gln-OH
EINECS	Contact for details

Quality Control

Our n-Phthalyl-D-Glutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.