Description

2,6-Bis[(4S)-Phenyl-2-Oxazolin-2-Yl]Pyridine is a chiral, C2-symmetric ligand belonging to the bis(oxazoline) family, a cornerstone in asymmetric catalysis. Its precise stereochemical control makes it indispensable for creating high-value, enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. This compound is primarily sought by research institutions and industrial manufacturers specializing in asymmetric hydrogenation, cyclopropanation, and Diels-Alder reactions, where it acts as a key component for chiral metal complexes.

Application

• As a chiral ligand for asymmetric catalysis, particularly in conjunction with transition metals like copper, iron, and palladium.
• Critical component in the synthesis of enantiomerically pure pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Facilitates asymmetric C–H activation and carbon–carbon bond-forming reactions in advanced organic synthesis.
• Used in academic and industrial R&D for developing novel catalytic systems and methodologies.
• Employed in the production of specialty chemicals requiring high optical purity.
• Applicable in asymmetric polymerization reactions to create polymers with specific chiral architectures.

Basic Information

Product Name	2,6-Bis[(4S)-Phenyl-2-Oxazolin-2-Yl]Pyridine
CAS No.	174500-20-0
Molecular Formula	C25H21N3O2
Molecular Weight	395.46 g/mol
Synonyms	(S,S)-2,6-Bis(4-phenyl-4,5-dihydrooxazol-2-yl)pyridine; (4S,4'S)-2,6-Bis(4-phenyl-2-oxazolin-2-yl)pyridine; PyBOX Ligand (S,S)-Ph; (S)-2,6-Bis(4-phenyl-4,5-dihydrooxazol-2-yl)pyridine; 2,6-Bis[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; (S,S)-2,6-Bis(4-phenyl-2-oxazolinyl)pyridine; Chiral Bis(oxazoline) Ligand
EINECS	Contact for details

Quality Control

Our 2,6-Bis[(4S)-Phenyl-2-Oxazolin-2-Yl]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation. We support customer audits and can provide material to meet the stringent requirements of cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.