Description

(1S,2S)-(-)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane CAS NO 174291-97-5 is a high-purity, chiral diamine derivative featuring a tosyl-protected amine group. This compound is a critical chiral building block and ligand in asymmetric synthesis, valued for its ability to induce high enantioselectivity in catalytic reactions. It is essential for research and production in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or precursor for catalysts in enantioselective hydrogenation, epoxidation, and C-C bond-forming reactions.
• Pharmaceutical Intermediates: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially for oncology and central nervous system (CNS) therapeutics.
• Chiral Auxiliary: Used to temporarily impart chirality during synthetic sequences to control the stereochemistry of new stereocenters.
• Resolution Agent: Employed in the separation of racemic mixtures of acids or other compounds via diastereomeric salt formation.
• Material Science Research: Investigated as a monomer or modifier for creating chiral polymers and advanced functional materials with specific optical properties.
• Academic & Industrial R&D: A standard reagent in method development and discovery chemistry within university and corporate research laboratories.

Basic Information

Product Name	(1S,2S)-(-)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane
CAS No.	174291-97-5
Molecular Formula	C13H20N2O2S
Molecular Weight	268.38 g/mol
Synonyms	(1S,2S)-(-)-1,2-Diaminocyclohexane N,N'-bis(4-methylbenzenesulfonamide); (1S,2S)-(-)-1,2-Diaminocyclohexane N,N'-di-p-toluenesulfonamide; (1S,2S)-(-)-DACH-Ts; (1S,2S)-(-)-1,2-Diaminocyclohexane N,N'-ditosylate; (1S,2S)-(-)-Ts-DACH; (-)-trans-1,2-Bis(p-toluenesulfonamido)cyclohexane; (1S,2S)-trans-N,N'-Ditosyl-1,2-diaminocyclohexane; (1S,2S)-(-)-N,N'-Ditosyl-1,2-diaminocyclohexane
EINECS	Contact for details

Quality Control

Our (1S,2S)-(-)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.