Description

(1R,2R)-(+)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane is a high-purity chiral diamine derivative, widely recognized as a key chiral ligand and building block in asymmetric synthesis. Its primary value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral auxiliaries to develop novel compounds with superior efficacy and safety profiles.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, epoxidation, and cyclopropanation.
• Pharmaceutical Intermediates: A critical building block in the synthesis of enantiomerically pure drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Chiral Resolution Agent: Used for the separation of racemic mixtures of acids or other compounds via diastereomeric salt formation.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides to enhance biological activity and reduce environmental impact.
• Material Science: Acts as a monomer or modifier in the synthesis of chiral polymers and advanced functional materials.
• Academic & Process R&D: A valuable tool for developing new synthetic methodologies and scaling up enantioselective processes in laboratory and pilot plant settings.

Basic Information

Product Name	(1R,2R)-(+)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane
CAS No.	174291-96-4
Molecular Formula	C13H20N2O2S
Molecular Weight	268.37 g/mol
Synonyms	(1R,2R)-(-)-1,2-Diaminocyclohexane N,N'-bis(4-methylbenzenesulfonamide); (1R,2R)-(+)-1,2-Diaminocyclohexane N,N'-di-p-toluenesulfonamide; (R,R)-Ts-DACH; (1R,2R)-(-)-1,2-Diaminocyclohexane N,N'-di-p-toluenesulfonyl derivative; (R,R)-DACH-Ts; (1R,2R)-N,N'-Bis(4-tolylsulfonyl)-1,2-diaminocyclohexane; (R,R)-1,2-Diaminocyclohexane bis(tosylate); (1R,2R)-1,2-Diaminocyclohexane N,N'-ditosylate
EINECS	Contact for details

Quality Control

Our (1R,2R)-(+)-n-(4-Toluenesulphonyl)-1,2-Diaminocyclohexane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for asymmetric synthesis and pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.