Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester is a specialized bifunctional chelating agent and a key intermediate in radiopharmaceutical development. Its core value lies in its ability to form exceptionally stable complexes with diagnostic and therapeutic radiometals, such as Gallium-68 and Lutetium-177, while providing a reactive site for conjugation to targeting biomolecules. This product is essential for researchers and manufacturers in the fields of nuclear medicine, molecular imaging, and targeted radiotherapy who require high-purity, reliable building blocks for novel radiopharmaceuticals.

Application

• Radiopharmaceutical Precursor: A critical intermediate for synthesizing DOTA-NHS ester derivatives used in peptide and antibody radiolabeling.
• PET Imaging Agent Development: Conjugation to targeting vectors for creating Gallium-68 (68Ga) based Positron Emission Tomography (PET) tracers.
• Targeted Radionuclide Therapy (TRT): Building block for therapeutic agents utilizing isotopes like Lutetium-177 (177Lu) or Actinium-225 (225Ac) for cancer treatment.
• Bifunctional Chelator (BFC) Synthesis: Serves as the activated ester form of DOTA, enabling efficient coupling to amines on proteins, peptides, or other biomolecules.
• Contrast Agent Research: Used in the development of advanced MRI contrast agents by complexing Gadolinium (Gd3+) ions.
• Molecular Probe Design: Facilitates the creation of dual-modal imaging probes by attaching both radioactive and fluorescent tags.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	170908-81-3
Molecular Formula	C22H32N6O10
Molecular Weight	540.53 g/mol
Synonyms	DOTA-NHS ester; DOTA-NHS; DOTA active ester; 2,5-Dioxopyrrolidin-1-yl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid N-hydroxysuccinimide ester; DOTA-tetra(t-butyl)ester NHS; DOTA tris(t-butyl) ester NHS; DOTA mono-NHS tris(t-butyl ester); DOTA(tBu)3-NHS
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.