Description

Lanepitant is a potent and selective non-peptide antagonist of the neurokinin-1 (NK1) receptor, a key target in neuropharmacology. Its primary value lies in its utility as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for advanced research and development. This compound is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on developing therapeutics for conditions like anxiety, depression, and emesis. Lanepitant CAS NO 170566-84-4 represents a critical building block in the discovery of next-generation central nervous system (CNS) drugs.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in API manufacturing.
• Neurokinin-1 (NK1) Receptor Research: Used as a selective tool compound in preclinical studies to investigate the role of substance P and NK1 receptors in pain, inflammation, and emotional processing.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic intermediate in the production of NK1 receptor antagonist drug candidates.
• Central Nervous System (CNS) Drug Discovery: Facilitates research into potential treatments for anxiety disorders, major depressive disorder (MDD), and chemotherapy-induced nausea and vomiting (CINV).
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to identify and characterize novel NK1 receptor modulators.
• Metabolism and Pharmacokinetic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the in-vivo behavior of NK1 antagonists.

Basic Information

Product Name	Lanepitant
CAS No.	170566-84-4
Molecular Formula	C27H30N2O3
Molecular Weight	430.54 g/mol
Synonyms	LY-306740; (2S,3S)-3-([(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-phenylpiperidin-3-yl)methyl)-5-methylmorpholin-2-one; (2S,3S)-2-(Diphenylmethyl)-N-[(3R)-2-oxo-5-phenyl-1,4-diazepan-3-yl]-1-azabicyclo[2.2.2]octane-3-carboxamide; NK1 Receptor Antagonist LY306740; Lanepitant (LY306740)
EINECS	Contact for details

Quality Control

Our Lanepitant is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Assay (HPLC)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.