Description

(R)-1,4-Ditosyloxy-2-Butanol is a high-value chiral building block and synthetic intermediate of significant importance in asymmetric organic synthesis. Its core value proposition lies in its well-defined stereochemistry and bifunctional tosylate groups, enabling precise and controlled construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure intermediates for developing active pharmaceutical ingredients (APIs), chiral ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drugs, particularly for cardiovascular and central nervous system (CNS) therapeutic agents.
• Asymmetric Catalyst Synthesis: Used to construct chiral ligands and organocatalysts for enantioselective transformations in fine chemical production.
• Agrochemical Development: Serves as a building block for chiral active ingredients in herbicides, fungicides, and insecticides, where specific stereochemistry is crucial for bioactivity.
• Polymer Science: Monomer for the synthesis of chiral polymers and functional materials with specific optical or mechanical properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and tools for studying biological systems and enzyme mechanisms.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and stereochemistry research at universities and corporate R&D centers.

Basic Information

Product Name	(R)-1,4-Ditosyloxy-2-Butanol
CAS No.	170305-50-7
Molecular Formula	C18H22O6S2
Molecular Weight	398.49 g/mol
Synonyms	(R)-1,4-Bis(tosyloxy)-2-butanol; (R)-1,4-Di-O-tosyl-2-butanol; (2R)-1,4-Bis[(4-methylphenyl)sulfonyl]oxybutan-2-ol; (R)-2-Butanol, 1,4-bis[(4-methylphenyl)sulfonyl]oxy-; (R)-1,4-Di-p-toluenesulfonyloxy-2-butanol; (R)-1,4-Di-O-toluenesulfonyl-2-butanol; (R)-1,4-Ditosyl-2-butanol; (R)-DTB
EINECS	Contact for details

Quality Control

Our (R)-1,4-Ditosyloxy-2-Butanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and titration for assay. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.