Description

D-4,4'-Biphenylalanine is a non-natural, chiral amino acid derivative featuring a rigid biphenyl core. This structural motif makes it a valuable building block in medicinal chemistry and advanced materials science, offering unique steric and electronic properties. It is primarily utilized by research institutions and pharmaceutical companies for the development of novel peptide-based therapeutics, enzyme inhibitors, and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide drugs, protease inhibitors, and other bioactive molecules targeting complex diseases.
• Peptidomimetics Research: Used to introduce conformational constraints and enhance metabolic stability in the design of novel peptidomimetic compounds.
• Ligand Synthesis: Serves as a precursor for chiral ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into specialty polymers and advanced organic materials to modify thermal stability and optical properties.
• Biochemical Tool: Employed in academic and industrial research to study protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	D-4,4'-Biphenylalanine
CAS No.	170080-13-4
Molecular Formula	C15H15NO2
Molecular Weight	241.29 g/mol
Synonyms	(R)-2-Amino-3-(1,1'-biphenyl-4-yl)propanoic acid; D-Biphenylalanine; D-BPA; (R)-4,4'-Biphenylalanine; D-4-Biphenylalanine; (R)-2-Amino-3-([1,1'-biphenyl]-4-yl)propanoic acid; (R)-3-(4-Phenylphenyl)alanine; D-4,4'-BPA
EINECS	Contact for details

Quality Control

Our D-4,4'-Biphenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.