Description

Talviraline is a synthetic antiviral compound with demonstrated activity against select RNA viruses, developed for research and preclinical development applications. Talviraline CAS NO 169312-27-0 is valued for its reproducible pharmacological profile and batch-to-batch consistency—critical for translational virology studies and lead optimization programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic virology centers engaged in antiviral mechanism-of-action studies and structure–activity relationship (SAR) analysis.

Application

• Antiviral drug discovery: Lead compound screening and hit-to-lead progression
• In vitro viral replication inhibition assays (e.g., SARS-CoV-2, influenza A, enterovirus models)
• Pharmacokinetic and metabolic stability profiling in hepatocyte and microsome systems
• Co-crystallization studies with viral polymerase or protease targets
• Reference standard for LC-MS/MS method development and validation
• Control material in antiviral cytotoxicity and selectivity index (SI) determination
• Formulation feasibility studies for oral and intravenous delivery routes
• Regulatory pre-submission batch characterization under ICH Q5 guidelines

Basic Information

Product Name	Talviraline
CAS No.	169312-27-0
Molecular Formula	C18H19ClN4O3S
Molecular Weight	406.89 g/mol
Synonyms	TLV-1; Talviralin; (R)-2-(4-Chlorophenyl)-N-((1S,2R)-2-hydroxy-1-(pyrimidin-2-yl)propyl)thiazole-4-carboxamide; 2-(4-Chlorophenyl)-N-[(1S,2R)-2-hydroxy-1-(2-pyrimidinyl)propyl]-4-thiazolecarboxamide; NSC 724992; AG-205/39121625; UNII-7XQZ3J8G2F; Talviraline hydrochloride (salt form, common in assay use)
EINECS	Not listed (no EINECS number assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time, NMR), assay (≥98.5% by HPLC), residual solvents (ICH Q3C compliant), heavy metals (≤10 ppm), and microbiological purity (absence of specified pathogens). Testing follows USP & EP general chapters where applicable, and all manufacturing adheres to ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent degradation. Due to its hygroscopic nature, maintain relative humidity below 30% and avoid repeated exposure to ambient air. Handle in a controlled environment with desiccated glove box or dry nitrogen purge when opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% – 101.0%
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits (e.g., acetone ≤ 5000 ppm, methanol ≤ 3000 ppm)
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.