Description

Cyclomarin A is a naturally occurring cyclic depsipeptide isolated from marine-derived Streptomyces bacteria, recognized for its potent and selective anti-inflammatory and immunomodulatory activity. It matters to research-driven pharmaceutical and biotech organizations seeking novel chemical probes for NF-κB pathway inhibition and macrophage polarization studies. Cyclomarin A CAS NO 169062-92-4 is primarily utilized by academic laboratories, contract research organizations (CROs), and early-stage drug discovery units focused on inflammation, oncology, and infectious disease targets.

Application

• Target validation studies for IKKβ and NF-κB signaling pathways in human macrophages and dendritic cells
• Lead compound screening in preclinical models of rheumatoid arthritis and inflammatory bowel disease (IBD)
• Chemical biology tool for investigating ubiquitin-proteasome system modulation in immune cells
• Structure-activity relationship (SAR) studies to develop optimized analogues with improved metabolic stability
• In vitro cytotoxicity profiling against cancer cell lines (e.g., HL-60, MCF-7) under controlled hypoxic conditions
• Co-crystallization substrate for X-ray structural analysis of protein–ligand complexes involving Cullin-RING E3 ligases
• Reference standard in LC-MS/MS method development for quantification in biological matrices
• Quality control reference material for biosynthetic pathway engineering of cyclomarin-producing actinomycete strains

Basic Information

Product Name	Cyclomarin A
CAS No.	169062-92-4
Molecular Formula	C58H85N11O14
Molecular Weight	1152.38 g/mol
Synonyms	Cyclomarin A; CYMA; Streptocyclomarin A; NSC 697917; CID 10163755; SCHEMBL12123733; BDBM50268003; AKOS030532826; UNII-7V6Q2J6Z7N; LS-187920; Z1141593767; 169062-92-4 (CAS); Cyclo-(D-Leu-L-Ile-D-allo-Thr-L-Val-L-Val-D-Val-L-Pro-L-Phe-D-Leu-L-Trp)
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (HPLC retention time match, HRMS, and IR spectral confirmation), purity (≥98.5% by HPLC-UV at 220 nm), and absence of microbial contamination (absence of viable bacteria and fungi per USP <61>). Testing adheres to ICH Q5, Q6A, and Q7 guidelines for biologically active natural products used in research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, maintain relative humidity below 30% during handling and storage. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (HRMS)	[M+H]+ m/z 1153.6324 ± 0.005 (calcd. for C58H86N11O14)
Assay (HPLC-UV)	≥98.5%
Related Substances	Individual impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents	MeOH ≤3000 ppm; Acetonitrile ≤410 ppm; Water ≤5.0%
Heavy Metals	≤10 ppm (as Pb)
Water Content (KF)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.