Description

3-Fluoro-4-Methylphenylboronic Acid is a high-purity organoboron compound, a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop active pharmaceutical ingredients (APIs), novel crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated and methylated biphenyl scaffolds found in various drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that benefit from the metabolic stability imparted by the fluorine and methyl substituents.
• Material Science Research: Serves as a monomer or building block for creating novel organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic and structural properties.
• Chemical Biology & Diagnostics: Employed in the synthesis of molecular probes, fluorescent tags, and sensor materials that utilize boronic acid chemistry for saccharide recognition or bioconjugation.
• Academic & Process R&D: A standard reagent in laboratory-scale organic synthesis and process development for method optimization and scale-up studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke fine chemicals and advanced intermediates under cGMP or ISO quality systems.

Basic Information

Product Name	3-Fluoro-4-Methylphenylboronic Acid
CAS No.	168267-99-0
Molecular Formula	C7H8BFO2
Molecular Weight	153.95 g/mol
Synonyms	(3-Fluoro-4-methylphenyl)boronic acid; 4-Methyl-3-fluorophenylboronic acid; 3-Fluoro-p-tolylboronic acid; B-(3-Fluoro-4-methylphenyl)boronic acid; 3-Fluoro-4-methylbenzeneboronic acid; 168267-99-0; Boronic acid, B-(3-fluoro-4-methylphenyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Methylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and other relevant analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.