Description

Agitoxin-2 CAS NO 168147-41-9 is a highly selective and potent peptide neurotoxin that specifically blocks voltage-gated potassium channels (Kv1.x family). This compound is a critical research tool in neuroscience and pharmacology for studying ion channel function, neuronal excitability, and related disease mechanisms. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neurological drug discovery and basic electrophysiology research.

Application

• Neuroscience Research: A key pharmacological tool for selectively inhibiting Kv1.1, Kv1.2, and Kv1.3 potassium channels in electrophysiological studies.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel modulators of potassium channels for therapeutic intervention.
• Ion Channel Characterization: Essential for defining the biophysical and pharmacological properties of recombinant or native potassium channels expressed in cell lines.
• Autoimmune Disease Research: Investigated in studies related to Kv1.3 channel roles in T-cell activation and potential targets for autoimmune conditions like multiple sclerosis.
• Toxicology & Venom Studies: Serves as a reference standard in the study of scorpion venom peptides and their mechanisms of action.
• Academic Teaching: Used in advanced university laboratories to demonstrate principles of neurotoxin action and patch-clamp electrophysiology techniques.

Basic Information

Product Name	Agitoxin-2
CAS No.	168147-41-9
Molecular Formula	C185H274N52O53S7
Molecular Weight	~4210.9 g/mol
Synonyms	AgTx2; Agitoxin 2; Leiurotoxin I; Iberiotoxin; Kaliotoxin; KTX; Neurotoxin BmKTX; Potassium channel toxin α-KTx 3.6; ShK toxin analogue
EINECS	Contact for details

Quality Control

Our Agitoxin-2 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and bioactivity data upon request, supporting research reproducibility and compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in aqueous buffers
Biological Activity (IC50, Kv1.3)	≤ 1 nM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.