Description

(S)-(-)-2,2'-Bis[Di(3,5-Di-T-Butylphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand essential for advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to optimize stereoselective hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral pharmaceutical intermediates.
• Pharmaceutical Intermediate Synthesis: Critical for the production of single-enantiomer active pharmaceutical ingredients (APIs), including those for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and insecticides where biological activity is stereospecific.
• Asymmetric Cross-Coupling Reactions: Facilitates enantioselective C-C and C-X bond-forming reactions for constructing complex chiral molecules.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for chiral compounds.
• Academic & Industrial R&D: A valuable tool for methodological development in asymmetric synthesis and catalyst discovery.

Basic Information

Item	Details
Product Name	(S)-(-)-2,2'-Bis[Di(3,5-Di-T-Butylphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	167709-31-1
Molecular Formula	C68H92O2P2
Molecular Weight	1011.41 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-(-)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-3,3'-Di-tert-butyl-5,5',6,6'-tetramethoxy-2,2'-bis[bis(3,5-di-tert-butylphenyl)phosphino]-1,1'-biphenyl; SEGPHOS derivative; Chiral bisphosphine ligand DTBM-SEGPHOS
EINECS	Contact for details

Quality Control

Our (S)-DTBM-SEGPHOS is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by HPLC, 1H/31P NMR, and specific optical rotation analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (ee), and identity is provided with every shipment, supporting cGMP and ISO standards for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Chiral Purity (Enantiomeric Excess)	Min. 99.0% ee
Specific Optical Rotation [α]	Contact for details
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.