Description

Tenofovir Diphosphate is the active diphosphate metabolite of the antiviral prodrug Tenofovir. This compound is a critical nucleotide analog that serves as a direct inhibitor of viral reverse transcriptase enzymes. It is an essential reference standard and key intermediate for researchers and manufacturers in the pharmaceutical industry, particularly in the development and quality control of antiviral therapies. The product is supplied under the identifier CAS NO 166403-66-3.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Antiviral Drug Research: Serves as a critical biochemical tool and direct active agent in virology research, specifically for studying HIV-1, HIV-2, and Hepatitis B virus (HBV) inhibition mechanisms.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and production of Tenofovir-based prodrugs such as Tenofovir Disoproxil Fumarate (TDF) and Tenofovir Alafenamide (TAF).
• Biochemical Assay Development: Utilized in enzymatic assays to study reverse transcriptase activity and screen for novel antiviral compounds.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic (PK/PD) studies to understand the intracellular activation pathway of Tenofovir.

Basic Information

Product Name	Tenofovir Diphosphate
CAS No.	166403-66-3
Molecular Formula	C9H14N5O10P2
Molecular Weight	429.18 g/mol
Synonyms	Tenofovir-DP; PMPA-DP; (R)-9-(2-Phosphonylmethoxypropyl)adenine Diphosphate; (R)-PMPA Diphosphate; GS-1278 Diphosphate; 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethoxy]methoxy]phosphinyl]methoxy]propyl]adenine Diphosphate; TDF Active Metabolite; Tenofovir PPi
EINECS	Contact for details

Quality Control

Our Tenofovir Diphosphate is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.