Description

D-Proline, 4-Methyl-, Ethyl Ester, (4R)-Rel- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This high-purity building block is valued for its role in constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and modulate biological activity.
• Agrochemical Research: Serves as a building block for developing chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel chiral catalysts and ligands for asymmetric catalysis.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Production: Used in the custom synthesis of high-value, optically pure compounds for various industrial applications.

Basic Information

Product Name	D-Proline, 4-Methyl-, Ethyl Ester, (4R)-Rel- (9Ci)
CAS No.	165273-05-2
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(4R)-4-Methyl-D-proline ethyl ester; Ethyl (4R)-4-methyl-D-prolinate; D-4-Methylproline ethyl ester; (R)-4-Methylproline ethyl ester; (2R,4R)-4-Methylpyrrolidine-2-carboxylic acid ethyl ester; Ethyl (2R,4R)-4-methylpyrrolidine-2-carboxylate; (4R)-rel-4-Methyl-D-proline ethyl ester; (9CI)
EINECS	Contact for details

Quality Control

Our production of D-Proline, 4-Methyl-, Ethyl Ester, (4R)-Rel- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC/MS to confirm identity, enantiomeric excess (ee), and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.