Description

3-(1H-Imidazol-1-Yl)-5-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional organic building block that combines a benzoic acid core with imidazole and trifluoromethyl substituents. This unique structure makes it a critical intermediate for the synthesis of advanced pharmaceuticals and agrochemicals, where it imparts desirable properties such as metabolic stability and enhanced bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in oncology, anti-infective, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the imidazole moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis.
• Material Science Research: Investigated for incorporation into advanced polymers, metal-organic frameworks (MOFs), or organic electronic materials due to its rigid, functionalized aromatic structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-(1H-Imidazol-1-Yl)-5-(Trifluoromethyl)Benzoic Acid
CAS No.	164341-38-2
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	5-(Trifluoromethyl)-3-(1H-imidazol-1-yl)benzoic acid; 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)benzoic acid; Benzoic acid, 3-(1H-imidazol-1-yl)-5-(trifluoromethyl)-; 3-Imidazol-1-yl-5-trifluoromethylbenzoic acid; 1-[3-Carboxy-5-(trifluoromethyl)phenyl]imidazole; 164341-38-2
EINECS	Contact for details

Quality Control

Our 3-(1H-Imidazol-1-Yl)-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP standards, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.