Description

(2R,3R,4S,5R)-2-(6-Amino-2-(3,3,3-Trifluoropropylthio)-9H-Purin-9-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral or anticancer therapeutics, leveraging its modified purine structure. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside analog prodrugs and antiviral agents.
• Antiviral Drug Research: Investigated as a potential active component in therapies targeting viral polymerases, particularly for hepatitis and other viral infections.
• Oncology Research: Explored for its potential antimetabolite activity in the development of targeted cancer chemotherapies.
• Biochemical Tool Compound: Used in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and related biological pathways.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies for new chemical entities (NCEs).
• Process Chemistry & Scale-up: Utilized in route scouting, optimization, and pilot-scale manufacturing of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2R,3R,4S,5R)-2-(6-Amino-2-(3,3,3-Trifluoropropylthio)-9H-Purin-9-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol
CAS No.	163706-51-2
Molecular Formula	C14H18F3N5O4S
Molecular Weight	409.38 g/mol
Synonyms	2-(6-Amino-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 6-Amino-2-(3,3,3-trifluoropropylthio)-9-β-D-ribofuranosyl-9H-purine; 2-(3,3,3-Trifluoropropylthio)adenosine derivative; 2-S-(3,3,3-Trifluoropropyl)-6-mercaptopurine riboside (modified); 9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-amine; TFPA nucleoside analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2R,3R,4S,5R)-2-(6-Amino-2-(3,3,3-Trifluoropropylthio)-9H-Purin-9-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure identity, strength, and composition. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your critical R&D and regulatory filing activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.