Description

Vilazodone Hydrochloride is a high-purity active pharmaceutical ingredient (API) primarily used as a selective serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. This dual mechanism of action makes it a critical component in the formulation of antidepressant medications, offering a distinct therapeutic profile. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant tablets.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Clinical Research: Used in preclinical and clinical studies for investigating new therapeutic applications or formulations.
• Generic Drug Development: A key material for companies developing bioequivalent generic versions of branded antidepressant medications.
• Pharmacological Studies: Employed in academic and industrial research to study serotonin receptor interactions and neuropharmacology.

Basic Information

Product Name	Vilazodone Hydrochloride
CAS No.	163521-08-2
Molecular Formula	C26H27N5O2·HCl
Molecular Weight	478.0 g/mol (as hydrochloride salt)
Synonyms	Vilazodone HCl; SB-659746A; 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide hydrochloride; EMD-68843; Viibryd (brand name) API; Vilazodone (base)
EINECS	Contact for details

Quality Control

Our Vilazodone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.