Description

2-Chloro-6-(Diphenylphosphino)Pyridine is a versatile and highly valuable organophosphorus ligand with a pyridine backbone. Its primary commercial significance lies in its ability to coordinate with transition metals, forming highly active and selective catalysts for a range of cross-coupling and other organic transformations. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over reaction pathways to synthesize complex molecules efficiently.

Application

• As a key ligand in homogeneous catalysis, particularly for palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Heck, Negishi).
• Development of specialized catalyst systems for C-H activation and functionalization, enabling more direct synthetic routes.
• Use in asymmetric synthesis when incorporated into chiral catalyst frameworks for the production of enantiomerically pure intermediates.
• Research and scale-up of active pharmaceutical ingredients (APIs) and key agrochemical intermediates requiring high-yield coupling steps.
• Fabrication of metal-organic frameworks (MOFs) and coordination polymers for material science applications.
• As a precursor or modifying agent for surface chemistry and the development of supported catalysts.

Basic Information

Product Name	2-Chloro-6-(Diphenylphosphino)Pyridine
CAS No.	162753-00-6
Molecular Formula	C17H13ClNP
Molecular Weight	297.72 g/mol
Synonyms	2-Chloro-6-(diphenylphosphanyl)pyridine; 6-Chloro-2-(diphenylphosphino)pyridine; (6-Chloro-2-pyridinyl)diphenylphosphine; 2-(Diphenylphosphino)-6-chloropyridine; Diphenyl(6-chloro-2-pyridyl)phosphine; P,P-Diphenyl-P-(6-chloro-2-pyridyl)phosphine; 162753-00-6; Ligand for cross-coupling
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-6-(Diphenylphosphino)Pyridine adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is characterized by modern analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting your quality management systems and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.