Description

4-Difluoromethoxy-3-Methoxy-Benzoic Acid is a high-purity, multi-functional benzoic acid derivative distinguished by its difluoromethoxy and methoxy substituents. This compound is a critical pharmaceutical intermediate valued for its role in synthesizing advanced active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Difluoromethoxy-3-Methoxy-Benzoic Acid
CAS No.	162401-59-4
Molecular Formula	C9H8F2O4
Molecular Weight	218.16 g/mol
Synonyms	3-Methoxy-4-(difluoromethoxy)benzoic Acid; Benzoic acid, 4-(difluoromethoxy)-3-methoxy-; 4-(Difluoromethoxy)-3-methoxybenzoic acid; 4-(Difluoromethoxy)-m-anisic Acid; DFMOBA; 162401-59-4
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxy-3-Methoxy-Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.