Description

Z-Glutamic Acid 5-Benzyl Ester Nca is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptide chains with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a critical monomer for the controlled, sequential addition of glutamic acid residues while protecting the side-chain carboxyl group.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing peptide fragments in solution, offering flexibility in synthetic routes.
• Pharmaceutical Intermediate: A key raw material in the research and production of peptide-based drugs, including hormones, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides with tags, dyes, or other functional molecules for diagnostic and research applications.
• Academic and R&D Laboratories: Employed in medicinal chemistry and biochemistry research to study protein-protein interactions and develop new bioactive compounds.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of bespoke peptides for clients worldwide.

Basic Information

Product Name	Z-Glutamic Acid 5-Benzyl Ester Nca
CAS No.	161990-08-5
Molecular Formula	C19H17NO6
Molecular Weight	355.34 g/mol
Synonyms	N-Carboxy-DL-glutamic Acid 5-Benzyl Anhydride; Z-Glu(OBzl)-NCA; N-Carboxy-DL-glutamic Acid γ-Benzyl Ester Anhydride; Z-DL-Glutamic Acid 5-Benzyl Ester N-Carboxyanhydride; Benzyl N-Carboxy-DL-glutamate Anhydride; Z-Glu(OBzl)-NCA; Glutamic Acid, N-carboxy-, 5-benzyl ester, anhydride; (Benzyloxycarbonyl)glutamic Acid γ-Benzyl Ester NCA
EINECS	Contact for details

Quality Control

Our Z-Glutamic Acid 5-Benzyl Ester Nca is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can compromise product integrity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.