Description

N2-Benzyloxycarbonyl-N6-tert-Butoxycarbonyl-L-Lysine Carboxylic Anhydride is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block, enabling the controlled and selective elongation of peptide chains in complex pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the production of novel therapeutic peptides, APIs, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of lysine residues with orthogonal side-chain protection.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptide fragments and small proteins in solution.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the manufacturing of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to create diverse arrays of peptide-like molecules.
• Biochemical Research: Used in academic and industrial labs to study protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	N2-Benzyloxycarbonyl-N6-tert-Butoxycarbonyl-L-Lysine Carboxylic Anhydride
CAS No.	161990-04-1
Molecular Formula	C20H26N2O7
Molecular Weight	406.43 g/mol
Synonyms	Z-Lys(Boc)-OH Anhydride; Nα-Z-Nε-Boc-L-Lysine NCA; Nα-Cbz-Nε-Boc-L-Lysine N-Carboxy Anhydride; (S)-5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic Acid; Boc-Lys(Z)-NCA; Z-Lys(Boc)-NCA; Fmoc-Lys(Boc)-OH Anhydride (common misnomer, verify structure); Lysine derivative, N2-Cbz-N6-Boc- anhydride
EINECS	Contact for details

Quality Control

Every batch of N2-Benzyloxycarbonyl-N6-tert-Butoxycarbonyl-L-Lysine Carboxylic Anhydride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for demanding research and cGMP manufacturing environments. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles by HPLC is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.