Description

R(+)-N,n-Bis(2-Diphenylphosphinoethyl)-1-Phenylethylamine CAS NO 161583-25-1 is a chiral, bidentate phosphine ligand widely used in asymmetric catalysis. This compound is highly valued for its ability to induce enantioselectivity in transition metal-catalyzed reactions, enabling the production of optically pure intermediates and active pharmaceutical ingredients (APIs). It is an essential tool for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to create high-value chiral molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral amines, amino acids, and alcohols.
• Pharmaceutical Intermediate Synthesis: Critical for the development of chiral APIs, including antidepressants, antivirals, and cardiovascular drugs.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric C-C and C-X bond-forming reactions for high-value specialty chemicals and flavors/fragrances.
• Academic & Industrial R&D: A versatile catalyst component for developing new synthetic methodologies in organic chemistry.
• Chiral Auxiliary Preparation: Used in the synthesis of other chiral ligands and auxiliaries for catalytic systems.

Basic Information

Product Name	R(+)-N,n-Bis(2-Diphenylphosphinoethyl)-1-Phenylethylamine
CAS No.	161583-25-1
Molecular Formula	C36H37NP2
Molecular Weight	545.64 g/mol
Synonyms	(R)-N,N-Bis(2-(Diphenylphosphino)ethyl)-1-Phenylethanamine; (R)-N,N-Bis[2-(Diphenylphosphino)ethyl]-α-Methylbenzeneethanamine; (R)-Bis[(2-Diphenylphosphino)ethyl]phenylmethylamine; (R)-Josiphos-type Ligand; (R)-N,N-Bis(2-(Diphenylphosphanyl)ethyl)-1-Phenylethan-1-amine; (R)-1-Phenylethylamine-N,N-bis(2-diphenylphosphinoethyl); (R)-Cyclohexyl-Josiphos Analog (Phenyl variant); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized to confirm identity, purity, and enantiomeric excess (ee). Standard analytical techniques include NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) with detailed specifications are available upon request. We adhere to cGMP principles for production where required, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and degradation. For long-term stability, keep the container in a cool, dry, well-ventilated area separate from strong oxidizing agents. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.