Description

4,5-Bis(Diphenylphosphino)-9,9-Dimethylxanthene is a specialized bidentate phosphine ligand widely recognized for its electron-rich and sterically demanding properties. This compound is crucial for facilitating challenging cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates and advanced organic materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for catalysis and material science applications.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed C-C and C-N bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used in the catalytic synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science & OLED Development: Facilitates the synthesis of conjugated polymers and organic light-emitting diode (OLED) precursors.
• Academic & Industrial R&D: Serves as a valuable tool for methodological development in organic synthesis and catalysis research.
• Fine Chemical Manufacturing: Applied in the production of high-value, specialty chemicals requiring precise catalytic control.

Basic Information

Item	Details
Product Name	4,5-Bis(Diphenylphosphino)-9,9-Dimethylxanthene
CAS No.	161265-03-8
Molecular Formula	C39H32OP2
Molecular Weight	578.62 g/mol
Synonyms	Xantphos; 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene; 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene; XantPhos Ligand; DPPX; XPhos (Note: XPhos is a different ligand, but a common mis-search); Xantphos Pd G2 Precatalyst; Bidentate Phosphine Ligand
EINECS	Contact for details

Quality Control

Our 4,5-Bis(Diphenylphosphino)-9,9-Dimethylxanthene is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. All products undergo rigorous analytical testing, including NMR, HPLC, and elemental analysis, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, containers should be purged with inert gas before resealing after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.