Description

(4R)-4-Isobutyl-2-Oxazolidinone is a high-value, chiral oxazolidinone derivative widely utilized as a versatile chiral auxiliary and building block in asymmetric synthesis. Its primary commercial value lies in its ability to induce high stereoselectivity in critical bond-forming reactions, enabling the production of enantiomerically pure pharmaceutical intermediates. This compound is essential for research and development chemists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity chiral reagents for complex synthetic routes.

Application

• As a chiral auxiliary in Evans aldol reactions and related asymmetric alkylations for the synthesis of stereodefined β-hydroxy carbonyl compounds.
• Key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) and complex natural products requiring specific stereochemistry.
• Building block for the preparation of novel ligands and catalysts used in enantioselective transformations.
• Intermediate in the research and development of agrochemicals, such as herbicides and fungicides with chiral centers.
• Used in academic and industrial R&D for methodology development in organic and medicinal chemistry.
• Precursor for the synthesis of specialized polymers and materials with tailored optical or physical properties.

Basic Information

Product Name	(4R)-4-Isobutyl-2-Oxazolidinone
CAS No.	161106-42-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(R)-4-Isobutyl-2-oxazolidinone; (4R)-4-(2-Methylpropyl)-1,3-oxazolidin-2-one; (R)-(-)-4-Isobutyl-2-oxazolidinone; Evans Auxiliary Derivative; (R)-4-Isobutyloxazolidin-2-one; (R)-N-Isobutyloxycarbonyl-2-oxazolidinone; (R)-4-(2-Methylpropyl)-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our (4R)-4-Isobutyl-2-Oxazolidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing, including chiral HPLC, NMR, and optical rotation measurement, to confirm identity, purity, and stereochemical integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.