Description

6H-Purin-6-One, 1,9-Dihydro-9-[Tetrahydro-5-(Hydroxymethyl)-2-Furanyl]-, (2S-Cis)- is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer agents, where its specific stereochemistry is essential for biological activity. It is primarily required by R&D laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a reference standard and precursor in enzymatic studies and metabolic pathway investigations.
• Antiviral Drug Development: Serves as a core structural component for the research and production of experimental antiviral compounds.
• Oncology Research: Employed in the discovery and development of chemotherapeutic agents that target DNA/RNA synthesis.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Provides a valuable tool for universities and research institutes studying nucleic acid chemistry and medicinal chemistry.

Basic Information

Product Name	6H-Purin-6-One, 1,9-Dihydro-9-[Tetrahydro-5-(Hydroxymethyl)-2-Furanyl]-, (2S-Cis)-
CAS No.	160962-90-3
Molecular Formula	C10H12N4O4
Molecular Weight	252.23 g/mol
Synonyms	9-[(2S,5R)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-9H-purin-6-ol; (2S,5R)-5-(Hydroxymethyl)-2-[(6-oxo-1H-purin-9-yl)]tetrahydrofuran; Carbocyclic Isoguanosine; c-IsoG; Carba-isoguanosine; NSC 760494; A nucleoside analog of isoguanosine
EINECS	Contact for details

Quality Control

Our 6H-Purin-6-One, 1,9-Dihydro-9-[Tetrahydro-5-(Hydroxymethyl)-2-Furanyl]-, (2S-Cis)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral HPLC to confirm stereochemical integrity, ensuring compliance with research-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.