Description

n-tert-Butoxycarbonyl-L-Glutamic Acid n-Carboxylic Anhydride is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block for the controlled introduction of glutamic acid residues, enabling the creation of complex peptides and other bioactive molecules. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in peptide synthesis, drug discovery, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of glutamic acid while protecting the side-chain carboxylic acid group.
• Solution-Phase Peptide Chemistry: Used in the synthesis of peptide fragments and conjugates where precise control over stereochemistry is required.
• Pharmaceutical Intermediates: Serves as a vital precursor in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs containing glutamic acid motifs.
• Bioconjugation and Linker Chemistry: Employed to attach peptides or other molecules to carriers, surfaces, or fluorescent probes via its reactive anhydride group.
• Research & Development: Utilized in academic and industrial labs for exploring new synthetic methodologies and creating custom peptide libraries.
• Synthesis of Glutamate-Based Neuroactive Compounds: A starting material for developing compounds that interact with glutamate receptors.

Basic Information

Product Name	n-tert-Butoxycarbonyl-L-Glutamic Acid n-Carboxylic Anhydride
CAS No.	160803-29-2
Molecular Formula	C10H15NO6
Molecular Weight	245.23 g/mol
Synonyms	Boc-Glu(OBzl)-OH anhydride; Boc-L-Glutamic Acid 5-Benzyl Ester N-Carboxy Anhydride; N-(tert-Butoxycarbonyl)-L-glutamic Acid 1-(Benzyl Ester) 5-Anhydride; NCA-Boc-Glu(OBzl); Nα-Boc-glutamic acid γ-benzyl ester N-carboxyanhydride; (4R)-4-[(2-Methylpropan-2-yl)oxycarbonylamino]-5-oxo-4,5-dihydrofuran-2-carboxylic acid benzyl ester; Boc-Glu-OBzl NCA; Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester, anhydride with carbonic acid
EINECS	Contact for details

Quality Control

Our n-tert-Butoxycarbonyl-L-Glutamic Acid n-Carboxylic Anhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We employ advanced analytical techniques, including HPLC, NMR, and chiral analysis, to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	[α]20/D: Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.