Description

Apricitabine CAS NO 160707-69-7 is a potent nucleoside reverse transcriptase inhibitor (NRTI) developed for antiviral therapy. This compound is of significant interest for its potential application in the treatment of HIV-1 infection, particularly in cases involving drug-resistant viral strains. It is primarily utilized by pharmaceutical research organizations, contract development and manufacturing organizations (CDMOs), and academic institutions engaged in antiviral drug discovery and development.

Application

• Antiviral Drug Development: Serves as a key active pharmaceutical ingredient (API) in preclinical and clinical research for novel HIV therapeutics.
• Biochemical Research: Used as a reference standard and probe compound in virology and molecular biology studies to investigate reverse transcriptase mechanisms.
• Pharmaceutical Intermediates: Acts as a critical synthetic intermediate in the production of more complex nucleoside analog drugs.
• Resistance Studies: Employed in research focused on understanding and overcoming HIV resistance to existing NRTI treatments.

Basic Information

Product Name	Apricitabine
CAS No.	160707-69-7
Molecular Formula	C8H11FN4O3S
Molecular Weight	262.26 g/mol
Synonyms	AVX754; SPD754; (-)-dOTC; 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; 2'-Deoxy-3'-oxa-4'-thiocytidine; BCH-10652; dOTC; Coviracil analog
EINECS	Contact for details

Quality Control

Our Apricitabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.