Description

Diisopropyl Tenofovir Fumarate is a key pharmaceutical intermediate and prodrug form of Tenofovir, an important nucleotide reverse transcriptase inhibitor. This compound is critical for ensuring the stability and bioavailability of the final active pharmaceutical ingredient (API) in antiviral formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of antiviral medications, particularly for the treatment of HIV and hepatitis B.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of Tenofovir Disoproxil Fumarate (TDF), the active pharmaceutical ingredient.
• Antiviral Drug Synthesis: Serves as a building block in the manufacturing of nucleotide analog reverse transcriptase inhibitors (NRTIs).
• Research & Development: Used in medicinal chemistry research for developing new antiviral compounds and prodrug strategies.
• Generic Drug Manufacturing: Essential for producers of generic antiviral medications requiring a reliable, high-quality intermediate.
• API Production: Integral to the controlled synthesis and scale-up processes for final API production under GMP guidelines.
• Formulation Development: Supports studies on drug stability, solubility, and bioavailability in pre-formulation stages.

Basic Information

Product Name	Diisopropyl Tenofovir Fumarate
CAS No.	160616-04-6
Molecular Formula	C₁₉H₃₀N₅O₇P • C₄H₄O₄
Molecular Weight	Contact for details
Synonyms	Tenofovir Diisopropyl Ester Fumarate; (R)-9-(2-((Bis((isopropoxycarbonyl)oxy)phosphinyl)methoxy)propyl)adenine Fumarate; PMPA Diisopropyl Ester Fumarate; GS 4331 Diisopropyl Ester Fumarate; Bis(POC)PMPA Fumarate; 1-(((2R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)-2-(diisopropoxyphosphinyl)ethoxyethyl Fumarate; Diisopropyl [[(2R)-1-(6-amino-9H-purin-9-yl)-2-propan-2-yloxy]methoxy]phosphoryl]methyl Fumarate
EINECS	Contact for details

Quality Control

Our Diisopropyl Tenofovir Fumarate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing specifications for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP and ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.