Description

4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl)Pyrimidin-2(1H)-One is a high-purity nucleoside analogue intermediate of significant commercial and research importance. This compound is valued for its role as a key building block in the synthesis of complex antiviral and pharmaceutical active ingredients. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in nucleoside chemistry and drug development. Our supply ensures consistent quality and reliable availability for critical R&D and production processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Drug Research: Serves as a key scaffold for developing active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Biochemical Research: Used in enzymatic studies and as a substrate or inhibitor in biochemical assays related to nucleotide metabolism.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of specialty pharmaceuticals.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: Acts as a starting material for the custom synthesis of labeled compounds (e.g., deuterated, C13) for metabolic studies.

Basic Information

Product Name	4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl)Pyrimidin-2(1H)-One
CAS No.	160552-54-5
Molecular Formula	C8H11N3O4S
Molecular Weight	245.26 g/mol
Synonyms	4-Amino-1-((2R,3R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone 3-oxide; Lamivudine Impurity; (-)-2'-Deoxy-3'-thiacytidine 3-Oxide; 3-Oxo-lamivudine; BCH-455; Oxathiolane Cytosine Derivative; 1,3-Oxathiolane Nucleoside Intermediate; 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl)Pyrimidin-2(1H)-One is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and compliance with customer specifications and relevant industry guidelines. Comprehensive Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.