Description

3,5-Difluoro-4-(2,2,2-Trifluoroethoxy)Phenyl-Boronicacid is a high-value, multi-fluorinated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles by incorporating the difluoro and trifluoroethoxy motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and OFETs, due to its ability to fine-tune electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the creation of fluorinated molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3,5-Difluoro-4-(2,2,2-trifluoroethoxy)phenylboronic acid
CAS No.	160483-71-6
Molecular Formula	C8H6BF5O3
Molecular Weight	255.94 g/mol
Synonyms	[4-(2,2,2-Trifluoroethoxy)-3,5-difluorophenyl]boronic acid; 3,5-Difluoro-4-(2,2,2-trifluoroethoxy)benzeneboronic acid; B-[3,5-Difluoro-4-(2,2,2-trifluoroethoxy)phenyl]boronic acid; (3,5-Difluoro-4-(trifluoroethoxy)phenyl)boronic acid; Boronic acid, B-[3,5-difluoro-4-(2,2,2-trifluoroethoxy)phenyl]-; 160483-71-6; CAS 160483-71-6
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(2,2,2-Trifluoroethoxy)Phenyl-Boronicacid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.