Description

Fomivirsen is a synthetic antisense oligonucleotide designed for targeted therapeutic intervention. This compound is significant for its specific mechanism of action, which involves binding to complementary messenger RNA sequences to inhibit viral protein synthesis. It is primarily required by pharmaceutical research and development organizations, biotechnology firms, and advanced therapeutic manufacturers focused on antiviral applications and novel drug modalities.

Application

• Antiviral Research & Development: Serves as a key active pharmaceutical ingredient (API) in the investigation and formulation of treatments for cytomegalovirus (CMV) retinitis, particularly in immunocompromised patients.
• Ophthalmic Pharmaceutical Manufacturing: Used in the production of intravitreal injectable solutions for localized treatment of ocular viral infections.
• Mechanistic Studies: Employed as a tool compound in molecular biology and pharmacology to study antisense technology and gene expression inhibition pathways.
• Preclinical & Clinical Development: Acts as a reference standard and a critical component in the development and validation of bioanalytical methods for pharmacokinetic and pharmacodynamic studies.
• Advanced Therapy Medicinal Product (ATMP) Development: Investigated for its potential in next-generation therapeutic platforms, including combination therapies.

Basic Information

Product Name	Fomivirsen
CAS No.	160369-77-7
Molecular Formula	C204H263N63O114P20S20
Molecular Weight	7121.0 g/mol (approximately)
Synonyms	Fomivirsen Sodium; ISIS 2922; Vitravene; 5'-d(TSGSCSTSTSCSGSCSTSTSTSCSGSCSTSTS)-3'; Antisense oligonucleotide (sequence: 5'-GCG TTT GCT CTT CTT CGT GC-3'); Phosphorothioate Oligodeoxynucleotide
EINECS	Contact for details

Quality Control

Our Fomivirsen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and consistency, meeting the stringent requirements for pharmaceutical-grade oligonucleotides. Certificates of Analysis (COA) detailing specifications such as assay, purity by HPLC, endotoxin levels, and sterility (where applicable) are provided to support regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (Ion-Exchange HPLC)	Full-length oligonucleotide ≥ 85.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Oligonucleotide Sequence	5'-GCG TTT GCT CTT CTT CGT GC-3' (Phosphorothioate backbone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.