Description

L-Glutamine (5-13C) is a stable isotope-labeled analog of the essential amino acid L-Glutamine, where the carbon atom at the 5-position is enriched with the 13C isotope. This compound is critical for advanced metabolic research, enabling precise tracking and quantification of glutamine utilization in biological systems. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in metabolomics, drug development, and nutritional studies where accurate tracer analysis is required.

Application

• Isotope Tracer Studies: Used in in vitro and in vivo metabolic flux analysis (MFA) to map glutamine pathways in cancer, immunology, and cell culture research.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS and GC-MS assays for the quantitative analysis of glutamine and related metabolites in biological matrices.
• Biomedical Research: Facilitates investigations into glutamine's role in cellular energetics, ammonia detoxification, and nucleotide synthesis.
• Nutritional Science: Employed in stable isotope probing studies to understand protein synthesis, turnover, and the metabolic fate of dietary glutamine.
• Pharmaceutical Development: Critical for the development and validation of bioanalytical methods for new therapeutic agents targeting glutamine metabolism.

Basic Information

Product Name	L-Glutamine (5-13C)
CAS No.	159680-32-7
Molecular Formula	C413CH10N2O3
Molecular Weight	147.13 g/mol (for 99% 13C enrichment)
Synonyms	(2S)-2-Amino-4-carbamoyl-5-(13C)butanoic acid; L-Glutamine-5-13C; (5-13C)-L-Glutamine; Glutamine-5-13C; L-Gln-5-13C; 13C Labeled L-Glutamine; Stable Isotope Labeled Glutamine
EINECS	Contact for details

Quality Control

Our L-Glutamine (5-13C) is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch undergoes comprehensive analysis, including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and chiral analysis to confirm stereochemical integrity. Certificates of Analysis (COA) detailing all specifications, including isotopic purity (typically ≥99 atom % 13C), are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (MS)	≥99 atom % 13C
Optical Rotation	[α]D20: +6.0° to +8.0° (c=1 in H2O)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.