Description

n-Methyl-Valyl-4-Cyclosporin A is a chemically modified derivative of the potent immunosuppressive cyclic peptide, Cyclosporin A. This specific analog is of significant interest for pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in immunology, drug discovery, and advanced medicinal chemistry.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel Cyclosporin derivatives with modified pharmacological profiles.
• Immunosuppressant Studies: For investigating the mechanisms of immunosuppression and calibrating bioassays related to T-cell function and cytokine expression.
• Structure-Activity Relationship (SAR) Analysis: Critical for academic and industrial research aiming to understand how specific amino acid modifications affect the potency, selectivity, and toxicity of Cyclosporin analogs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related peptide-based pharmaceuticals using techniques like HPLC and LC-MS.
• Preclinical Drug Candidate: Serves as a potential lead compound in the development of next-generation immunosuppressive or anti-inflammatory therapies.

Basic Information

Product Name	n-Methyl-Valyl-4-Cyclosporin A
CAS No.	159605-70-6
Molecular Formula	C63H113N11O12
Molecular Weight	1208.65 g/mol
Synonyms	N-Methyl-L-valyl-4-cyclosporin A; [N-Methyl-L-valine]4-Cyclosporin A; Cyclosporin A, 4-(N-methyl-L-valyl)-; [MeVal]4-Cyclosporin A; 4-(N-Methylvalyl)cyclosporin A; CsA-[MeVal]4; (4-[N-Methyl-L-valine])-Cyclosporin A
EINECS	Contact for details

Quality Control

Our n-Methyl-Valyl-4-Cyclosporin A is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the product label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.