Description

Adenosine-13C5 is a stable isotope-labeled analog of adenosine, where five carbon atoms are replaced with the 13C isotope. This product is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is a critical material for researchers and manufacturers in pharmaceutical development, clinical diagnostics, and advanced biochemical research requiring precise isotopic tracing.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a high-purity internal standard for the accurate quantification of endogenous adenosine and related nucleotides in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of nucleoside-based pharmaceuticals.
• Clinical Research & Diagnostics: Enables precise measurement of adenosine levels in plasma, serum, and tissue samples for research into cardiovascular, neurological, and inflammatory conditions.
• Metabolic Flux Analysis: A key tracer for 13C-isotope labeling experiments to map and quantify metabolic pathways in cell cultures and model organisms.
• Pharmaceutical Reference Standard: Used for method development, validation, and quality control in the production of nucleoside drugs and APIs.
• Biochemical Research: Employed in enzymatic studies and receptor binding assays where a non-radioactive, isotopically labeled ligand is required.

Basic Information

Product Name	Adenosine-13C5
CAS No.	159496-13-6
Molecular Formula	C1013C5H13N5O4
Molecular Weight	272.21 g/mol (for 13C5 labeled form)
Synonyms	9-β-D-Ribofuranosyladenine-13C5; Adenine riboside-13C5; 6-Amino-9-β-D-ribofuranosyl-9H-purine-13C5; 13C5-Adenosine; [13C5]-Adenosine; Adenosine (13C5); Isotopically Labeled Adenosine; Stable Isotope-Labeled Adenosine
EINECS	Contact for details

Quality Control

Every batch of Adenosine-13C5 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure high chemical purity and isotopic enrichment, critical for sensitive analytical applications. Certificates of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic purity, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment (13C5)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.