Description

Boc-Asp(Obzl)-n-Carboxyanhydride is a protected amino acid derivative specifically engineered as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled, sequential addition of aspartic acid with its side-chain protected, enabling the synthesis of complex peptides with high fidelity and minimal side reactions. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental monomer for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Serves as a precursor for introducing aspartic acid residues into proteins or other biomolecules for modification studies.
• Biochemical Research: Employed in academic and industrial labs to study protein-protein interactions, enzyme substrates, and receptor ligands.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.
• Production of Protected Peptide Fragments: For fragment condensation strategies in the synthesis of long or challenging peptide chains.

Basic Information

Product Name	Boc-Asp(Obzl)-n-Carboxyanhydride
CAS No.	159396-59-5
Molecular Formula	C17H19NO7
Molecular Weight	349.34 g/mol
Synonyms	Boc-Asp(OBzl)-NCA; Nα-Boc-L-aspartic acid β-benzyl ester N-carboxyanhydride; N-tert-Butoxycarbonyl-L-aspartic acid β-benzyl ester anhydride; Boc-L-Aspartic acid β-benzyl ester NCA; Boc-Asp-OBzl NCA; (S)-4-((tert-Butoxycarbonyl)amino)-5-oxo-5-((phenylmethoxy)amino)-4,5-dihydrofuran-2(3H)-one; NCA of Boc-Asp(OBzl); Boc-Asp(β-OBzl)-NCA
EINECS	Contact for details

Quality Control

Our Boc-Asp(Obzl)-n-Carboxyanhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DCM; slightly soluble in ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.