Description

28-o-Methyl-Rapamycin is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, Rapamycin (Sirolimus). This compound is of significant interest in biochemical and pharmaceutical research for probing the structure-activity relationships of rapamycin analogs and developing novel therapeutic agents. It serves as a critical intermediate and reference standard for researchers in immunology, oncology, and aging research.

Application

• Biochemical Research: Used as a key reference standard and intermediate in studying the mTOR signaling pathway and its role in cell growth, proliferation, and autophagy.
• Pharmaceutical Development: Serves as a crucial building block for the synthesis of novel rapamycin analogs with potential improved pharmacokinetic profiles or targeted therapeutic effects.
• Immunology Studies: Employed in research to investigate immunosuppressive mechanisms and develop next-generation immunomodulators.
• Oncology Research: Utilized in preclinical studies to explore the anti-proliferative effects of mTOR inhibitors on various cancer cell lines.
• Anti-aging & Longevity Research: Acts as a research tool in studies investigating the role of mTOR inhibition in lifespan extension and age-related diseases.
• Metabolic Disorder Research: Applied in studies exploring the connection between mTOR signaling and conditions like diabetes and obesity.

Basic Information

Item	Detail
Product Name	28-o-Methyl-Rapamycin
CAS No.	159351-88-9
Molecular Formula	C52H81NO14
Molecular Weight	944.20 g/mol
Synonyms	28-O-Methylrapamycin; 28-O-Methyl-sirolimus; 28-Methoxyrapamycin; 28-Methoxy-sirolimus; 28-O-Methyl Rapamycin; 28-O-Methyl Sirolimus; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
EINECS	Contact for details

Quality Control

Our 28-o-Methyl-Rapamycin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere after each use to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.