Description

40-O-[2-(T-Butyldimethylsilyl)Oxy]Ethyl Rapamycin is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin (sirolimus). This compound is a critical advanced pharmaceutical intermediate designed for the synthesis of next-generation rapamycin analogs with tailored pharmacokinetic and pharmacodynamic properties. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutics for oncology, immunosuppression, and anti-aging research.

Application

• Key Intermediate for Novel Rapalogs: Serves as a pivotal building block for synthesizing ester and ether derivatives of rapamycin with enhanced solubility or targeting.
• Preclinical Drug Discovery: Used in medicinal chemistry programs to explore structure-activity relationships (SAR) of mTOR pathway inhibitors.
• Bioconjugation & Prodrug Development: The silyl-protected hydroxyl group allows for selective deprotection and further functionalization, enabling the creation of antibody-drug conjugates (ADCs) or prodrugs.
• Chemical Biology Research: Employed as a tool compound to study mTOR signaling and cellular processes like autophagy and senescence.
• Process Chemistry & Scale-Up: Supplied to CROs and CDMOs for the development and optimization of scalable synthetic routes for candidate drugs.

Basic Information

Product Name	40-O-[2-(T-Butyldimethylsilyl)Oxy]Ethyl Rapamycin
CAS No.	159351-68-5
Molecular Formula	C56H91NO14Si
Molecular Weight	1034.41 g/mol
Synonyms	40-O-[2-(tert-Butyldimethylsilyl)oxyethyl]rapamycin; 40-O-(2-((tert-Butyldimethylsilyl)oxy)ethyl)sirolimus; TBDMS-O-Ethyl Rapamycin; Rapamycin, 40-O-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-; 40-O-(2-Hydroxyethyl)rapamycin 2-(tert-butyldimethylsilyl) ether; CCI-779 Intermediate (Temsirolimus precursor analog)
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under controlled conditions and undergoes rigorous analytical characterization. Quality is assured through HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.