Description

10,11-Dehydro-2-Acetoxytrimipramine is a high-purity chemical intermediate of significant interest in advanced pharmaceutical research and development. Its value lies in its role as a key synthetic precursor for the development and study of novel tricyclic antidepressant analogs and related central nervous system (CNS) active compounds. This product is essential for research chemists and process development scientists in pharmaceutical companies and contract research organizations (CROs) focused on neuropharmacology.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel tricyclic antidepressant compounds and their derivatives.
• Active Pharmaceutical Ingredient (API) Research: Serves as a precursor in the research and development of new chemical entities (NCEs) targeting serotonin and norepinephrine reuptake pathways.
• Metabolite Studies: Used in the synthesis of reference standards for pharmacokinetic and metabolic pathway analysis of trimipramine and related drugs.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of specialized CNS-active pharmaceuticals.
• Biochemical Research: Utilized in *in vitro* studies to investigate structure-activity relationships (SAR) of tricyclic compounds at neurotransmitter receptors.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory compliance in API manufacturing.

Basic Information

Product Name	10,11-Dehydro-2-Acetoxytrimipramine
CAS No.	158798-74-4
Molecular Formula	C24H28N2O2
Molecular Weight	376.50 g/mol
Synonyms	2-Acetoxy-10,11-didehydrotrimipramine; 10,11-Didehydro-2-acetoxytrimipramine; 5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl acetate; 10,11-Dehydro-2-O-acetyltrimipramine; Trimipramine Impurity; Desmethyltrimipramine Acetate Derivative
EINECS	Contact for details

Quality Control

Our 10,11-Dehydro-2-Acetoxytrimipramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.