Description

D-Proline, 1-Methylethyl Ester (9Ci) is a chiral, non-proteinogenic amino acid derivative, specifically the isopropyl ester of D-proline. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), peptides, and other fine chemicals where the D-proline configuration is required. Its defined stereochemistry makes it valuable for creating molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the synthesis of modified peptides and peptidomimetics, where the D-configuration of proline can influence secondary structure and biological stability.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral catalysts, ligands, and auxiliaries used in enantioselective transformations.
• Agrochemical Research: Employed in the research and development of chiral pesticides and herbicides.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research projects.
• Fine Chemical Synthesis: An intermediate for producing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	D-Proline, 1-Methylethyl Ester (9Ci)
CAS No.	158630-13-8
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	D-Proline isopropyl ester; (R)-1-(Isopropoxycarbonyl)pyrrolidine-2-carboxylic acid; Isopropyl D-prolinate; D-Pro-O-iPr; (R)-Pyrrolidine-2-carboxylic acid isopropyl ester; 1-Methylethyl (2R)-pyrrolidine-2-carboxylate; (R)-2-Carboxypyrrolidine isopropyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Methylethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture, which can affect quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.