Description

2-[1,2-13C2]Acetamido-2-Deoxy-D-Glucose is a stable isotope-labeled derivative of N-acetylglucosamine, a fundamental building block in glycobiology. This compound is essential for advanced metabolic and biochemical research, providing a critical tool for precise tracing and quantification in complex biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in drug metabolism studies, biomarker discovery, and glycan analysis.

Application

• Metabolic Pathway Tracing: Used as a stable isotope-labeled precursor in in vitro and in vivo studies to track the incorporation and flux of glucosamine in glycosylation pathways.
• Drug Development & Pharmacokinetics: Serves as an internal standard in LC-MS/MS and GC-MS assays for the quantitative analysis of drug metabolites and endogenous compounds related to hexosamine biosynthesis.
• Glycobiology Research: A key substrate for studying enzymes like glycosyltransferases and glycosidases, enabling research into cell signaling, protein function, and disease mechanisms.
• Diagnostic Assay Development: Employed in the calibration and validation of mass spectrometry-based clinical diagnostic tests for metabolic disorders.
• Biomarker Discovery: Facilitates the accurate identification and quantification of novel carbohydrate-based biomarkers in proteomics and metabolomics.
• Nutritional Science: Applied in research investigating the metabolism of amino sugars and their role in joint health and inflammation.

Basic Information

Product Name	2-[1,2-13C2]Acetamido-2-Deoxy-D-Glucose
CAS No.	157668-96-7
Molecular Formula	C8H1513C2NO6
Molecular Weight	Contact for details
Synonyms	N-Acetyl-D-[1,2-13C2]glucosamine; [1,2-13C2]-N-Acetylglucosamine; 2-Acetamido-2-deoxy-D-[1,2-13C2]glucose; D-[1,2-13C2]GlcNAc; Labeled N-Acetyl-D-glucosamine; Stable Isotope-Labeled NAG; Acetylglucosamine-13C2; 2-(Acetylamino)-2-deoxy-D-[1,2-13C2]glucopyranose
EINECS	Contact for details

Quality Control

Every batch of 2-[1,2-13C2]Acetamido-2-Deoxy-D-Glucose is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific analytical data (NMR, MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.