Description

tert-Butyl 2-Fluoro-4-Nitrobenzoate is a high-purity, specialized organic intermediate featuring a nitro and a fluorine substituent on a benzoate ester framework. This compound is valued for its role as a versatile building block in advanced synthetic chemistry, enabling the introduction of both electron-withdrawing and halogen functionalities. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of complex active molecules, including potential drug candidates and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the nitro and fluorine groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology & Proteomics: Employed as a building block for creating molecular probes, tags, and linkers used in studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 2-Fluoro-4-Nitrobenzoate
CAS No.	157665-46-8
Molecular Formula	C11H12FNO4
Molecular Weight	241.22 g/mol
Synonyms	2-Fluoro-4-nitrobenzoic acid tert-butyl ester; Benzoic acid, 2-fluoro-4-nitro-, 1,1-dimethylethyl ester; tert-Butyl 2-fluoro-4-nitrobenzoate; 1,1-Dimethylethyl 2-fluoro-4-nitrobenzoate; 2-Fluoro-4-nitro-benzoic acid tert-butyl ester; t-Butyl 2-fluoro-4-nitrobenzoate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-Fluoro-4-Nitrobenzoate is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.