Description

2,4-Difluoro-3-(trifluoromethyl)benzoic Acid is a high-value fluorinated aromatic building block characterized by its unique substitution pattern. This compound is essential for introducing both fluorine atoms and a trifluoromethyl group into complex molecular architectures, significantly altering physicochemical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives, where fluorination enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and trifluoromethyl motifs contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where its structure helps fine-tune electronic properties and stability.
• Polymer & Material Science: Employed to create specialty monomers and polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Cross-Coupling Reactions: The carboxylic acid functionality allows for easy conversion to acid chlorides, esters, or amides, making it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex, fluorinated heterocycles in academic and industrial R&D settings.

Basic Information

Product Name	2,4-Difluoro-3-(trifluoromethyl)benzoic Acid
CAS No.	157337-81-0
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	2,4-Difluoro-3-(trifluoromethyl)benzoic Acid; 3-(Trifluoromethyl)-2,4-difluorobenzoic Acid; 2,4-Difluoro-α,α,α-trifluoro-m-toluic Acid; Benzoic acid, 2,4-difluoro-3-(trifluoromethyl)-; 2,4-Difluoro-3-trifluoromethylbenzoic Acid; 157337-81-0 (CAS); 2,4-Difluoro-α,α,α-trifluoro-m-toluic Acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-(trifluoromethyl)benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.