Description

D-[1,6-13C2,6,6'-2H2]Glucose is a high-purity, multi-isotope labeled glucose derivative, specifically designed for advanced analytical and metabolic research. This compound is essential for providing precise internal standards in mass spectrometry and enabling detailed, non-invasive metabolic flux analysis. It is a critical reagent for researchers and scientists in the pharmaceutical, biotechnology, and academic sectors who require the highest level of isotopic purity and traceability for their studies in metabolism, diagnostics, and stable isotope probing.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates in cell cultures, tissues, and whole organisms.
• Mass Spectrometry (MS) Internal Standard: Serves as a high-precision internal standard for the accurate quantification of glucose and its metabolites in complex biological samples via GC-MS or LC-MS.
• NMR Spectroscopy: Employed in 13C and 2H NMR studies to investigate metabolic pathways and enzyme mechanisms without radioactive labels.
• Pharmaceutical R&D: Critical for drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their effects on host metabolism.
• Clinical Research & Diagnostics: Applied in research for metabolic disorders (e.g., diabetes, cancer) to understand disease-specific alterations in glucose metabolism.
• Stable Isotope Probing (SIP): Used in environmental microbiology to trace nutrient assimilation by microbial communities in complex ecosystems.

Basic Information

Product Name	D-[1,6-13C2,6,6'-2H2]Glucose
CAS No.	157171-80-7
Molecular Formula	C6H102H213C2O6
Molecular Weight	184.15 g/mol (for 13C2, 2H2 labeled form)
Synonyms	D-Glucose-1,6-13C2,6,6'-2H2; [1,6-13C2,6,6'-2H2]-D-Glucose; Isotopically Labeled D-Glucose; D-Glucose (1,6-13C2, 6,6-d2); Stable Isotope Labeled Glucose; 13C2,2H2-Glucose; Metabolic Tracer Glucose; D-Glucose-13C2,-d2 (1,6;6,6')
EINECS	Contact for details

Quality Control

Every batch of D-[1,6-13C2,6,6'-2H2]Glucose is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and MS analysis, to verify isotopic enrichment, positional labeling, and chemical identity. Certificates of Analysis (COA) detailing batch-specific isotopic purity (atom % 13C and 2H), chemical purity, and analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to labeled structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C at positions 1 & 6
Isotopic Enrichment (2H)	≥ 98 atom % 2H at positions 6,6'
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	+52.5° to +53.5° (c=10 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.