Description

8-Azabicyclo[3.2.1]Octane-2-Carboxylicacid,8-Methyl-3-Oxo-,Methylester,(1R-Exo)-,(2R,3R)-2,3-Dihydroxybutanedioate(1:1)(9Ci) is a high-purity, stereochemically defined bicyclic organic compound, primarily supplied as a salt to enhance stability and handling. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of complex molecular architectures. It is essential for research and production in the pharmaceutical and fine chemical industries, where precise stereochemistry and high purity are non-negotiable for successful outcomes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective reactions to construct complex natural products and bioactive molecules.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies due to its rigid, three-dimensional bicyclic scaffold.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, catalysts, and ligands where high enantiomeric purity is required.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new chemical spaces.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octane-2-Carboxylicacid,8-Methyl-3-Oxo-,Methylester,(1R-Exo)-,(2R,3R)-2,3-Dihydroxybutanedioate(1:1)(9Ci)
CAS No.	156857-14-6
Molecular Formula	C14H21NO9
Molecular Weight	347.32 g/mol
Synonyms	(1R-exo)-8-Methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester (2R,3R)-2,3-dihydroxybutanedioate (1:1); 8-Methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester, (1R,2S,5S)-rel-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1); Tropane-2-carboxylic acid, 8-methyl-3-oxo-, methyl ester, (1R,2S,5S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1); Methyl (1R,2S,5S)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate (R,R)-tartrate; Exo-8-Methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester L-(+)-tartrate salt
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to rigorous quality control protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through modern analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment. We support development and commercial projects with quality standards suitable for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.