Description

11(S)-Hepe is a specialized, high-purity eicosapentaenoic acid (EPA) derivative, specifically the 11(S)-hydroxy form, with the CAS registry number 156473-26-6. This compound serves as a critical biochemical standard and research-grade reference material for studying lipid metabolism and inflammatory pathways. It is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and advanced life science sectors who require precise, well-characterized bioactive lipid mediators for product development and analytical applications.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for the quantification and identification of oxylipins and specialized pro-resolving mediators (SPMs) in biological samples via LC-MS/MS.
• Pharmaceutical R&D: Serves as a key intermediate or active metabolite in the development of novel anti-inflammatory and immunomodulatory therapeutics targeting resolvin and protectin pathways.
• Nutraceutical Analysis: Employed as an analytical standard to assay the purity and potency of ω-3 fatty acid supplements and functional food products.
• Cell Biology Studies: Applied in in vitro and in vivo studies to investigate the role of specific EPA-derived metabolites in inflammation resolution, cell signaling, and tissue repair.
• Diagnostic Kit Development: Utilized in the formulation and calibration of enzyme immunoassay (EIA) or ELISA kits designed to detect lipid-based biomarkers.
• Academic Research: A vital tool for universities and research institutes exploring lipidomics, eicosanoid biology, and metabolic disorders.

Basic Information

Product Name	11(S)-Hepe
CAS No.	156473-26-6
Molecular Formula	C20H30O3
Molecular Weight	318.45 g/mol
Synonyms	11(S)-HpEPE; 11(S)-Hydroxy-5Z,8Z,12E,14Z,17Z-eicosapentaenoic acid; 11(S)-HEPE; 11S-HEPE; (11S)-Hydroxy-5Z,8Z,12E,14Z,17Z-eicosapentaenoic Acid; 11(S)-Hydroxyeicosapentaenoic Acid; 11S-Hydroxy-EPA; 11S-HpEPE
EINECS	Contact for details

Quality Control

Our 11(S)-Hepe is produced under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research and analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant GMP and ISO guidelines for the handling of high-value reference standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Quantitative NMR)	≥ 90% (w/w)
Enantiomeric Excess (Chiral HPLC)	≥ 98% (11S)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.