Description

Ivabradine is a highly selective and specific inhibitor of the If ("funny") current in cardiac pacemaker cells. This compound is a cornerstone active pharmaceutical ingredient (API) used in the treatment of chronic heart failure and stable angina pectoris. It is primarily utilized by pharmaceutical manufacturers and research institutions for the development and production of finished dosage forms. Our supply of Ivabradine CAS NO 155974-00-8 is manufactured under strict quality control to ensure the purity and consistency required for critical therapeutic applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of oral tablets for cardiovascular diseases.
• Chronic Heart Failure Treatment: Used in medications to reduce the risk of hospitalization for worsening heart failure in adult patients with systolic dysfunction.
• Stable Angina Pectoris: Formulated into drugs for the symptomatic treatment of chronic stable angina in patients with normal sinus rhythm.
• Cardiac Rhythm Research: A valuable tool compound in preclinical and clinical research studying heart rate control and sinoatrial node function.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for the production of bioequivalent versions of branded medications.
• Reference Standard: Serves as a high-purity chemical reference standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	Ivabradine
CAS No.	155974-00-8
Molecular Formula	C27H36N2O5
Molecular Weight	468.59 g/mol
Synonyms	Procoralan; Coralan; S-16257; S16257; Ivabradine Hydrochloride; (3-{3-[({[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}methylamino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one); 2,3,4,5-Tetrahydro-7,8-dimethoxy-3-[3-[[(7S)-3,4-dimethoxy-10-methyl-10-azatricyclo[4.3.1.03,7]deca-1,3,5-trien-10-yl]methyl]-4-methoxyphenyl]-1H-3-benzazepin-2-one
EINECS	Contact for details

Quality Control

Our Ivabradine is produced in facilities adhering to current Good Manufacturing Practices (cGMP). Each batch undergoes rigorous analytical testing to ensure it meets stringent specifications for identity, purity, and potency. We provide comprehensive Certificates of Analysis (COA) that detail results from tests including HPLC assay, related substances, residual solvents, and heavy metals, ensuring full traceability and compliance with ICH guidelines and major pharmacopoeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Water (Karl Fischer)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.