Description

Fmoc-o-Butyl-L-Tyrosine n-Hydroxysuccinimide Ester is a high-purity, protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and controlled incorporation of modified tyrosine residues into peptide chains, enabling advanced research and development. It is essential for pharmaceutical researchers, biochemists, and CROs working on novel peptide therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the automated or manual synthesis of custom peptides containing O-alkylated tyrosine.
• Pharmaceutical R&D: Key intermediate in the development of peptide-based drugs, hormones, and targeted therapeutics.
• Bioconjugation: Used to create peptide-protein or peptide-small molecule conjugates for drug delivery systems and diagnostic probes.
• Chemical Biology: Enables the study of protein-protein interactions and signal transduction pathways through site-specific peptide modification.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the synthesis of peptide linkers for connecting cytotoxic payloads to antibodies.
• Material Science: Building block for creating peptide-based biomaterials and surface coatings with specific functional properties.

Basic Information

Product Name	Fmoc-o-Butyl-L-Tyrosine n-Hydroxysuccinimide Ester
CAS No.	155892-27-6
Molecular Formula	C32H34N2O7
Molecular Weight	558.63 g/mol
Synonyms	Fmoc-Tyr(OtBu)-OSu; Fmoc-O-tert-Butyl-L-tyrosine N-hydroxysuccinimide ester; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine N-succinimidyl ester; Fmoc-L-Tyrosine(O-t-butyl)-OSu; N-α-Fmoc-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester; Fmoc-Tyr(tBu)-OSu; Fmoc-Tyr(O-tert-Bu)-OSu
EINECS	Contact for details

Quality Control

Every batch of Fmoc-o-Butyl-L-Tyrosine n-Hydroxysuccinimide Ester is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.