Description

3,5-Bis(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated organic building block characterized by its cinnamic acid core flanked by two powerful electron-withdrawing trifluoromethyl groups. This unique structure is critical for modulating the physicochemical properties of advanced materials and active pharmaceutical ingredients, enhancing lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by R&D and process chemists in the pharmaceutical, agrochemical, and specialty materials sectors for the synthesis of novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for targets requiring enhanced bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its influence on molecular polarity and stability.
• Polymer Modification: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reactions and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Cinnamic Acid
CAS No.	155814-20-3
Molecular Formula	C₁₁H₆F₆O₂
Molecular Weight	284.16 g/mol
Synonyms	(E)-3-[3,5-Bis(trifluoromethyl)phenyl]acrylic acid; 3,5-Bis(trifluoromethyl)cinnamic acid; trans-3,5-Bis(trifluoromethyl)cinnamic acid; 3-(3,5-Bis(trifluoromethyl)phenyl)-2-propenoic acid; α,3,5-Bis(trifluoromethyl)cinnamic acid; 3,5-Bis(trifluoromethyl)benzeneacrylic acid; 155814-20-3; 3,5-Di(trifluoromethyl)cinnamic acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.